Gene information
Official symbol ITGAM
Official full name integrin subunit alpha M
Gene type protein-coding gene
Chromosome16p11.2
Alias symbolMAC-1; CD11b
Previous symbolCR3A; CD11B
Gene familyCD molecules; Integrin alpha subunits; Complement system regulators and receptors
Resources
Entrez Gene 3684
HGNC HGNC:6149
Ensembl ENSG00000169896
Vega OTTHUMG00000176612
UCSC uc002ebq.4
GO terms: 91 records
GO Description Category LogP Number of genes Detail
GO:0001774 microglial cell activation GO Biological Processes -13.1367436 11 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001846 opsonin binding GO Molecular Functions -7.66060590 6 More
GO:0001848 complement binding GO Molecular Functions -6.79568546 6 More
GO:0001910 regulation of leukocyte mediated cytotoxicity GO Biological Processes -7.82450130 11 More
GO:0001912 positive regulation of leukocyte mediated cytotoxicity GO Biological Processes -3.17989306 9 More
GO:0002269 leukocyte activation involved in inflammatory response GO Biological Processes -12.6026553 11 More
GO:0002274 myeloid leukocyte activation GO Biological Processes -20.6988408 25 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0002696 positive regulation of leukocyte activation GO Biological Processes -27.9249645 47 More
GO:0002697 regulation of immune effector process GO Biological Processes -33.2683521 48 More
GO:0002699 positive regulation of immune effector process GO Biological Processes -18.3926498 29 More
GO:0002705 positive regulation of leukocyte mediated immunity GO Biological Processes -8.38274670 14 More
GO:0003002 regionalization GO Biological Processes -7.48750854 38 More
GO:0005178 integrin binding GO Molecular Functions -20.5409412 26 More
GO:0006898 receptor-mediated endocytosis GO Biological Processes -6.77623895 13 More
GO:0006909 phagocytosis GO Biological Processes -7.82039874 17 More
GO:0006911 phagocytosis, engulfment GO Biological Processes -3.88108165 8 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0007160 cell-matrix adhesion GO Biological Processes -9.58867374 15 More
GO:0007229 integrin-mediated signaling pathway GO Biological Processes -5.80936917 16 More
GO:0007420 brain development GO Biological Processes -11.5572036 75 More
GO:0010324 membrane invagination GO Biological Processes -3.48951254 8 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0022411 cellular component disassembly GO Biological Processes -6.34931814 17 More
GO:0030667 secretory granule membrane GO Cellular Components -8.32957622 38 More
GO:0030900 forebrain development GO Biological Processes -11.1545964 48 More
GO:0031072 heat shock protein binding GO Molecular Functions -1.83303292 11 More
GO:0031341 regulation of cell killing GO Biological Processes -10.2641102 14 More
GO:0031343 positive regulation of cell killing GO Biological Processes -3.44182824 10 More
GO:0031589 cell-substrate adhesion GO Biological Processes -10.7590108 32 More
GO:0032386 regulation of intracellular transport GO Biological Processes -4.43340887 15 More
GO:0032928 regulation of superoxide anion generation GO Biological Processes -6.91942497 9 More
GO:0032930 positive regulation of superoxide anion generation GO Biological Processes -6.32323278 8 More
GO:0033157 regulation of intracellular protein transport GO Biological Processes -4.35957871 12 More
GO:0033218 amide binding GO Molecular Functions -9.50305686 47 More
GO:0033238 regulation of cellular amine metabolic process GO Biological Processes -3.34516618 7 More
GO:0033627 cell adhesion mediated by integrin GO Biological Processes -3.57905448 8 More
GO:0034330 cell junction organization GO Biological Processes -7.96624809 49 More
GO:0035579 specific granule membrane GO Cellular Components -4.58725293 14 More
GO:0042116 macrophage activation GO Biological Processes -15.3664951 15 More
GO:0042581 specific granule GO Cellular Components -15.6202777 22 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043523 regulation of neuron apoptotic process GO Biological Processes -14.5388618 39 More
GO:0043525 positive regulation of neuron apoptotic process GO Biological Processes -3.54364153 9 More
GO:0044853 plasma membrane raft GO Cellular Components -18.4542052 33 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045321 leukocyte activation GO Biological Processes -25.4958219 48 More
GO:0045921 positive regulation of exocytosis GO Biological Processes -5.75584660 9 More
GO:0048880 sensory system development GO Biological Processes -3.47450215 31 More
GO:0050778 positive regulation of immune response GO Biological Processes -17.2528761 40 More
GO:0050808 synapse organization GO Biological Processes -6.17744712 32 More
GO:0050839 cell adhesion molecule binding GO Molecular Functions -14.4506551 68 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050867 positive regulation of cell activation GO Biological Processes -31.2431659 51 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051047 positive regulation of secretion GO Biological Processes -32.2282376 71 More
GO:0051222 positive regulation of protein transport GO Biological Processes -13.8994291 46 More
GO:0051223 regulation of protein transport GO Biological Processes -25.2801266 81 More
GO:0060322 head development GO Biological Processes -11.995356 79 More
GO:0060341 regulation of cellular localization GO Biological Processes -10.5933083 72 More
GO:0061900 glial cell activation GO Biological Processes -13.6981492 12 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0070820 tertiary granule GO Cellular Components -12.1965297 19 More
GO:0070821 tertiary granule membrane GO Cellular Components -3.64814241 11 More
GO:0090322 regulation of superoxide metabolic process GO Biological Processes -9.31154255 13 More
GO:0097190 apoptotic signaling pathway GO Biological Processes -11.7839485 23 More
GO:0097242 amyloid-beta clearance GO Biological Processes -5.57650860 8 More
GO:0098609 cell-cell adhesion GO Biological Processes -15.7963965 69 More
GO:0098636 protein complex involved in cell adhesion GO Cellular Components -5.90313372 12 More
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules GO Biological Processes -5.22391282 28 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:0098883 synapse pruning GO Biological Processes -6.79133706 5 More
GO:0099024 plasma membrane invagination GO Biological Processes -3.65307119 8 More
GO:0110089 regulation of hippocampal neuron apoptotic process GO Biological Processes -4.66190148 3 More
GO:0150063 visual system development GO Biological Processes -3.59465978 31 More
GO:0150076 neuroinflammatory response GO Biological Processes -13.2187099 12 More
GO:0150146 cell junction disassembly GO Biological Processes -6.56194591 5 More
GO:1901214 regulation of neuron death GO Biological Processes -23.5458880 37 More
GO:1901216 positive regulation of neuron death GO Biological Processes -5.62852599 9 More
GO:1903307 positive regulation of regulated secretory pathway GO Biological Processes -2.97443173 8 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903532 positive regulation of secretion by cell GO Biological Processes -27.9542102 63 More
GO:1903829 positive regulation of protein localization GO Biological Processes -12.9651258 57 More
GO:1904951 positive regulation of establishment of protein localization GO Biological Processes -13.0308630 46 More
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling GO Biological Processes -7.80587066 38 More
GO:1905475 regulation of protein localization to membrane GO Biological Processes -3.01117711 17 More
GO:1905477 positive regulation of protein localization to membrane GO Biological Processes -1.94173448 10 More
GO:2000377 regulation of reactive oxygen species metabolic process GO Biological Processes -19.1025541 38 More
GO:2000379 positive regulation of reactive oxygen species metabolic process GO Biological Processes -15.0445998 16 More
KEGG pathways: 12 records
KEGG Description Category LogP Number of genes Detail
hsa04015 Rap1 signaling pathway KEGG Pathway -8.52596130 17 More
hsa04514 Cell adhesion molecules KEGG Pathway -5.33785320 11 More
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
hsa04640 Hematopoietic cell lineage KEGG Pathway -11.4657972 15 More
hsa04670 Leukocyte transendothelial migration KEGG Pathway -6.49203386 11 More
hsa04810 Regulation of actin cytoskeleton KEGG Pathway -10.0068804 19 More
hsa05133 Pertussis KEGG Pathway -13.2270528 15 More
hsa05134 Legionellosis KEGG Pathway -13.8022551 14 More
hsa05146 Amoebiasis KEGG Pathway -14.8474637 18 More
hsa05150 Staphylococcus aureus infection KEGG Pathway -9.38905356 13 More
hsa05152 Tuberculosis KEGG Pathway -14.5221547 22 More
hsa05202 Transcriptional misregulation in cancer KEGG Pathway -9.99536642 18 More
Drug-Gene interaction
view
Related drugs: 10 records
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
integrin alpha-M proteomics ischemic postconditioning[treatment (other)] acute ST elevation myocardial infarction Liu SH et al. Pak J Med Sci. 2016
All rights reserved: Soochow University Center for Systems Biology